I’ve seen several FROST Let’s Plays where the game eventually breaks because certain mods didn’t get deactivated when the player switched profiles.Survivors were showing up as Raiders and Gunners for starters. Given that NMM can’t seem to even properly handle mods with one profile with any sort of reliability, switching between multiple profiles opens the door to all sorts of problems with mods not being properly activated. It will activate/deactivate the mods in your mod list when you change profiles to match what you have activated for that profile. Personally, I find the way that NMM handles profiles to be just ain and simple.